Synthesis of New Hispolon Derived Pyrazole Sulfonamides for Possible Antitubercular and Antimicrobial Agents

Abstract. A series of 10 new hispolonpyrazole sulfonamides were designed and synthesized using hispolons 4-sulfonamide phenylhydrazine hydrochloride with better yields. The pyrazole screened for anti-TB, anti-bacterial, anti-fungal activities to compare the role sulfonamide moiety. Among them, 3a 3b showed selective potent anti-tubercular nature (MIC 6.25µg/mL). Further, antimicrobial studies compounds only compound a good inhibition zone on Staphylococcus aureus among other bacteria fungi studied.
 
 Resumen.Se prepararon nuevas hispolon-pirazol-suklfonamidas con buenos rendimientos haciendo reaccionar hipolonas y el clorhidrato de 4-sulfonamidil-fenílhidrazina. Los productos obtenidos se probaron contra cepas hongos bacterias especial interés en la tuberculosis, encontrando algunos derivados actividades del orden MIC 6.25µg/mL.